This guideline presents recommendations for the step-wise management of patients with
overt upper gastrointestinal bleeding. Hemodynamic status is first assessed, and …

Abstract Background/Aims: The incidence of uncomplicated peptic ulcer has decreased in
recent years. It is unclear what the impact of this has been on the epidemiology of peptic …

Peptic ulcer disease had a tremendous effect on morbidity and mortality until the last
decades of the 20th century, when epidemiological trends started to point to an impressive …

Guidelines for clinical practice are intended to indicate preferred approaches to medical
problems as established by scientifically valid research. Double-blind, placebo-controlled …

Description: A multidisciplinary group of 34 experts from 15 countries developed this update
and expansion of the recommendations on the management of acute nonvariceal upper …

The gastric mucosa maintains structural integrity and function despite continuous exposure
to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue …

Background Non‐steroidal anti‐inflammatory drugs (NSAIDs) are important agents in the
management of arthritic and inflammatory conditions, and are among the most frequently …

Summary Background Cyclo-oxygenase (COX)-2-selective non-steroidal anti-inflammatory
drugs (NSAIDs) and non-selective NSAIDs plus a proton-pump inhibitor (PPI) have similar …

OBJECTIVES: To discuss nonsteroidal anti-inflammatory drugs (NSAIDs), their history,
development, mode of action, toxicities, strategies for the prevention of toxicity, and future …

Pain Assessment and Pharmacologic Management, by highly renowned authors Chris
Pasero and Margo McCaffery, is destined to become the definitive resource in pain …