Metabotropic glutamate receptors: from the workbench to the bedside
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research
MJ Arranz, J De Leon - Molecular psychiatry, 2007 - nature.com
The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …
development of genetic tests to determine the patients' metabolic status and the first attempts …
Bipolar I disorder and schizophrenia: a 440–single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
MD Fallin, VK Lasseter, D Avramopoulos… - The American Journal of …, 2005 - cell.com
Bipolar, schizophrenia, and schizoaffective disorders are common, highly heritable
psychiatric disorders, for which familial coaggregation, as well as epidemiological and …
psychiatric disorders, for which familial coaggregation, as well as epidemiological and …
Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)
Conventional antipsychotic medication is ineffective in around a third of patients with
schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated …
schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated …
Molecular mechanisms of schizophrenia
Schizophrenia is a complex disorder, where family, twin and adoption studies have been
demonstrating a high heritability of the disease and that this disease is not simply defined by …
demonstrating a high heritability of the disease and that this disease is not simply defined by …
Correspondence between fMRI and SNP data by group sparse canonical correlation analysis
D Lin, VD Calhoun, YP Wang - Medical image analysis, 2014 - Elsevier
Both genetic variants and brain region abnormalities are recognized as important factors for
complex diseases (eg, schizophrenia). In this paper, we investigated the correspondence …
complex diseases (eg, schizophrenia). In this paper, we investigated the correspondence …
Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance
SYT Cherlyn, P San Woon, JJ Liu, WY Ong… - Neuroscience & …, 2010 - Elsevier
Schizophrenia (SZ) and bipolar disorder (BD) are debilitating neurobehavioural disorders
likely influenced by genetic and non-genetic factors and which can be seen as complex …
likely influenced by genetic and non-genetic factors and which can be seen as complex …
The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia
PJ Harrison, L Lyon, LJ Sartorius… - Journal of …, 2008 - journals.sagepub.com
Group II metabotropic glutamate receptors (mGluRs) comprise mGluR2 (mGlu2; encoded by
GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate …
GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate …
Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists
Drugs acting at metabotropic glutamate receptors (mGluRs) are among the most promising
agents under development for the treatment of psychiatric disorders. The research in this …
agents under development for the treatment of psychiatric disorders. The research in this …
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study
C Lavedan, L Licamele, S Volpi, J Hamilton… - Molecular …, 2009 - nature.com
A whole genome association study was performed in a phase 3 clinical trial conducted to
evaluate a novel antipsychotic, iloperidone, administered to treat patients with …
evaluate a novel antipsychotic, iloperidone, administered to treat patients with …