Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process

A Latka, B Maciejewska, G Majkowska-Skrobek… - Applied microbiology …, 2017 - Springer
Bacteriophages are bacterial viruses that infect the host after successful receptor recognition
and adsorption to the cell surface. The irreversible adherence followed by genome material …

Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications

Z Drulis-Kawa, G Majkowska-Skrobek… - Current Protein and …, 2012 - ingentaconnect.com
The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …

Antimicrobial bacteriophage-derived proteins and therapeutic applications

DR Roach, DM Donovan - Bacteriophage, 2015 - Taylor & Francis
Antibiotics have the remarkable power to control bacterial infections. Unfortunately,
widespread use, whether regarded as prudent or not, has favored the emergence and …

A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity Against Multidrug-Resistant Klebsiella pneumoniae via Biofilm …

Y Wu, R Wang, M Xu, Y Liu, X Zhu, J Qiu… - Frontiers in …, 2019 - frontiersin.org
The increasing prevalence of infections caused by multidrug-resistant Klebsiella
pneumoniae necessitates the development of alternative therapies. Here, we isolated …

Bacteriophages and phage-derived proteins–application approaches

Z Drulis-Kawa, G Majkowska-Skrobek… - Current medicinal …, 2015 - ingentaconnect.com
Currently, the bacterial resistance, especially to most commonly used antibiotics has proved
to be a severe therapeutic problem. Nosocomial and community-acquired infections are …

Phage φAB6-Borne Depolymerase Combats Acinetobacter baumannii Biofilm Formation and Infection

M Shahed-Al-Mahmud, R Roy, FG Sugiokto, MN Islam… - Antibiotics, 2021 - mdpi.com
Biofilm formation is one of the main causes of increased antibiotic resistance in
Acinetobacter baumannii infections. Bacteriophages and their derivatives, such as tail …

Phage-derived depolymerase: its possible role for secondary bacterial infections in COVID-19 patients

A Nazir, J Song, Y Chen, Y Liu - Microorganisms, 2023 - mdpi.com
As of 29 July 2022, there had been a cumulative 572,239,451 confirmed cases of COVID-19
worldwide, including 6,390,401 fatalities. COVID-19 patients with severe symptoms are …

Bacteriophages and their immunological applications against infectious threats

E Criscuolo, S Spadini, J Lamanna… - Journal of …, 2017 - Wiley Online Library
Bacteriophage therapy dates back almost a century, but the discovery of antibiotics led to a
rapid decline in the interests and investments within this field of research. Recently, the …

Paving the way forward: Escherichia coli bacteriophages in a One Health approach

A Oliveira, C Dias, R Oliveira, C Almeida… - Critical Reviews in …, 2024 - Taylor & Francis
Escherichia coli is one of the most notorious pathogens for its ability to adapt, colonize, and
proliferate in different habitats through a multitude of acquired virulence factors. Its presence …

The past, present, and future of enzyme-based therapies

JN Hennigan, MD Lynch - Drug discovery today, 2022 - Elsevier
Enzyme-based therapeutics (EBTs) have the potential to tap into an almost unmeasurable
amount of enzyme biodiversity and treat myriad conditions. Although EBTs were some of the …