Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …

Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in
DS patients may arise from imbalances in excitatory and inhibitory neurotransmission …

Stem cells with the capability to self-renew and differentiate into multiple cell derivatives
provide platforms for drug screening and promising treatment options for a wide variety of …

Transplanting human induced pluripotent stem cells (iPSCs)-derived spinal cord progenitor
cells (SCPCs) is a promising approach to treat spinal cord injuries. However, stem cell …

Cell cultures are used in pharmaceutical, medical and biological sciences. Due to the ethical
and cost limitations of in vivo models, the replaceable cell model that is more closely related …

Extracellular matrix (ECM) has long been known to regulate many aspects of neural
development in many different species. However, the role of the ECM in the development of …

Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …

Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its
instructive roles during development. Using developmental stage-sourced brain ECM in …