[HTML][HTML] Glycosylation of SARS-CoV-2: structural and functional insights
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Similar to other coronaviruses, its particles are composed of four structural …
(SARS-CoV-2). Similar to other coronaviruses, its particles are composed of four structural …
High-sensitivity analytical approaches for the structural characterization of glycoproteins
1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
[HTML][HTML] Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition
Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …
[HTML][HTML] A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP. 664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing …
RW Sanders, R Derking, A Cupo, JP Julien… - PLoS …, 2013 - journals.plos.org
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …
Rational HIV immunogen design to target specific germline B cell receptors
Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
Crystal structure of a soluble cleaved HIV-1 envelope trimer
HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env)
trimers that have been challenging to characterize structurally. Here, we describe the crystal …
trimers that have been challenging to characterize structurally. Here, we describe the crystal …
HIV-1 neutralizing antibodies induced by native-like envelope trimers
RW Sanders, MJ van Gils, R Derking, D Sok, TJ Ketas… - Science, 2015 - science.org
INTRODUCTION A major goal of HIV-1 vaccine development is to identify immunogens
capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against …
capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against …
[HTML][HTML] Global site-specific N-glycosylation analysis of HIV envelope glycoprotein
L Cao, JK Diedrich, DW Kulp, M Pauthner, L He… - Nature …, 2017 - nature.com
Abstract HIV-1 envelope glycoprotein (Env) is the sole target for broadly neutralizing
antibodies (bnAbs) and the focus for design of an antibody-based HIV vaccine. The Env …
antibodies (bnAbs) and the focus for design of an antibody-based HIV vaccine. The Env …
[HTML][HTML] Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein
AJ Behrens, S Vasiljevic, LK Pritchard, DJ Harvey… - Cell reports, 2016 - cell.com
The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that
shield it from immune surveillance. The high density of glycans on the trimer surface …
shield it from immune surveillance. The high density of glycans on the trimer surface …
[HTML][HTML] Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
New broad and potent neutralizing HIV-1 antibodies have recently been described that are
largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 …
largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 …