Biological information is stored by DNA and manifested by proteins. RNA serves as the
conduit: 1 The flow of information through RNA is essential for known life. By catalyzing the …

In organic molecules a divalent sulfur atom sometimes adopts weak coordination to a
proximate heteroatom (X). Such hypervalent nonbonded S··· X interactions can control the …

Fragment screening offers an alternative to traditional screening for discovering new leads
in drug discovery programs. This paper describes a fragment screening methodology based …

Despite recent advances in cryo-electron microscopy and artificial intelligence-based model
predictions, a significant fraction of structure determinations by macromolecular …

A method for the quantitative estimation of instability with respect to deamidation of the
asparaginyl (Asn) residues in proteins is described. The procedure involves the observation …

Scores calculated from intermolecular contacts of proteins in the crystalline state are used to
differentiate monomeric and homodimeric proteins, by classification into two categories …

A substrate for a hypersensitive assay of ribonucleo-lytic activity was developed in a
systematic manner. This substrate is based on the fluorescence quenching of fluorescein …

Preparation of proteins in their crystalline state has been found to be important in producing
stable therapeutic protein formulations, cross-linked enzyme crystals for application in …

Solution NMR spin-relaxation experiments were used to compare μs− ms dynamics in
RNase A in the apo form and as complexed to the substrate-mimic, pTppAp. The crystal …

The dynamic nature of protein structures has been recognized, established, and accepted
as an intrinsic fundamental property with major consequences to their function. Nowadays …