The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics
that ensure the somatic inheritance of differentiated state is defined as a crucial factor …

Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and
progression of lung cancer is the result of the interaction between permanent genetic and …

Lung cancer is one of the most common malignancies. In spite of the progress made in past
decades, further studies to improve current therapy for lung cancer are required …

Determining how histone acetylation is regulated is vital for treating the many diseases
associated with its misregulation, including heart disease, neurological disorders, and …

Abstract Histone deacetylase 10 (HDAC10) is a member of the class II HDACs, and its role
in cancer is emerging. In this study, we found that HDAC10 is highly expressed in lung …

Arsenic trioxide (ATO; As2O3) has anti-cancer effects in various solid tumors as well as
hematological malignancy. Valproic acid (VPA), which is known to be a histone deacetylase …

Lung cancer has a very high mortality in females and males. Most (~ 85%) of lung cancers
are non-small cell lung cancers (NSCLC). When lung cancer is diagnosed, most of them …

Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases.
The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) …

Lung cancer and cutaneous leishmaniasis are critical diseases with a relatively higher
incidence in developing countries. In this research, the activity of Carissa macrocarpa leaf …

Histone deacetylase inhibitors (HDIs) are a new class of drugs which affect the activity of
HDACs resulting in changed of acetylation in many proteins. HDIs can induce differentiation …