In the wake of the Human Genome Project (HGP), strong expectations were set for the
timeline and impact of genomics on medicine—an anticipated transformation in the …

Clinical genetic testing has grown substantially over the past 30 years as the causative
mutations for Mendelian diseases have been identified, particularly aided in part by the …

Abstract Introduction: Since 2005, disease-related human genetic diversity has been
intensively characterized using genome-wide association studies (GWAS). Understanding …

Motivation: Widespread availability of low-cost, full genome sequencing will introduce new
challenges for bioinformatics. Results: This review outlines recent developments in …

The increasing availability of genotype data linked with information about drug‐response
phenotypes has enabled genomewide association studies (GWAS) that uncover genetic …

Purpose: Sensory peripheral neuropathy is a common and sometimes debilitating toxicity
associated with paclitaxel therapy. This study aims to identify genetic risk factors for the …

Rationale: Albuterol, a bronchodilator medication, is the first-line therapy for asthma
worldwide. There are significant racial/ethnic differences in albuterol drug response …

Drug response varies between individuals owing to disease heterogeneity, environmental
factors, and genetic factors. Genetic factors can affect both the pharmacokinetics and …

Objective The assessment of response to lithium maintenance treatment in bipolar disorder
(BD) is complicated by variable length of treatment, unpredictable clinical course, and often …

Background Variability in drug efficacy and adverse effects are observed in clinical practice.
While the extent of genetic variability in classic pharmacokinetic genes is rather well …