Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated …

Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that
releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to …

Ca2+ signals are core transducers and regulators in many adaptation and developmental
processes of plants. Ca2+ signals are represented by stimulus-specific signatures that result …

The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …

Survival in the wild requires organismal adaptations to the availability of nutrients.
Endosomes and lysosomes are key intracellular organelles that couple nutrition and …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …