Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

It is clear that the well-described phenomenon of epithelial–mesenchymal transition (EMT)
plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ …

Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with
the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of …

Understanding the causal role of the immune and inflammatory responses in hypertension
has led to questions regarding the links between hypertension and autoimmunity. Immune …

Abstract Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-
differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive …

The treatment of lupus nephritis has changed significantly over the past decade in large part
because of data from well-conducted randomized clinical trials. The concept of two phases …

Atrial fibrillation (AF) is the most common sustained arrhythmia in the population and is
associated with a significant clinical and economic burden. Rigorous assessment of the …

Lupus glomerulonephritis is a prototype of immune complex disease mediated by
autoantibodies of multiple specificities, one of which is anti-DNA. Murine models of …

Systemic lupus erythematosus (SLE) is associated with a high burden of cardiovascular
disease (CVD), which is in part imputed to classical vascular risk factors such as …

Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase and
is crucial in the renin-angiotensin-aldosterone system (RAAS) but also implicated in immune …