Transcription factors (TFs) are essential players in orchestrating the regulatory landscape in
cells. Still, their exact modes of action and dependencies on other regulatory aspects remain …

Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause
congenital cataracts. We report the first single-cell multiomic atlas of lens development …

Organisms utilize gene regulatory networks (GRN) to make fate decisions, but the regulatory
mechanisms of transcription factors (TF) in GRNs are exceedingly intricate. A longstanding …

Recent developments in synthetic biology, next-generation sequencing, and machine
learning provide an unprecedented opportunity to rationally design new disease treatments …

The snATAC+ snRNA platform allows epigenomic profiling of open chromatin and gene
expression with single-cell resolution. The most critical assay step is to isolate high-quality …

The aging eye experiences physiological changes that include decreased visual function
and increased risk of retinal degeneration. Although there are transcriptomic signatures in …

Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the
hepatic microenvironment (ie, liver fibrosis) and portal hypertension. The dynamics of gene …

Skeletal muscle function crucially depends on innervation while repair of skeletal muscle
relies on resident muscle stem cells (MuSCs). However, it is poorly understood how …

Multicellular organisms originate from a single cell, ultimately giving rise to mature
organisms of heterogeneous cell type composition in complex structures. Recent work in the …

Background: Chromatin falls into one of two major subtypes: closed heterochromatin and
euchromatin which is accessible, transcriptionally active, and occupied by transcription …