Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …

Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …

The program package ATSAS 2.1 for small-angle X-ray and neutron scattering data analysis
is presented. The programs included in the package cover the major processing and …

Orientational restraints such as residual dipolar couplings promise to overcome many of the
problems that traditionally limited liquid-state nuclear magnetic resonance spectroscopy …

The use of anisotropic NMR data, such as residual dipolar couplings (RDCs) and residual
chemical shift anisotropies (RCSAs), has emerged as a powerful technique for structural …

The use of residual dipolar couplings (RDCs) in the analysis of biomolecular structure and
dynamics has expanded rapidly since its potential as a source of structural information on …

Much of postgenomic biochemistry and all of structural biology are based on the premise
that the starting point for both understanding specific biochemical processes, such as affinity …

DNA G-quadruplexes are essential motifs in molecular biology performing a wide range of
functions enabled by their unique and diverse structures. In this study, we focus on the …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …