Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling

P Ramesh, R Jagadeesan, S Sekaran… - Frontiers in …, 2021 - frontiersin.org
Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea
plants, and stems and many more natural commodities. They have a multitude of …

[HTML][HTML] Estrogenic flavonoids and their molecular mechanisms of action

R Kiyama - The Journal of Nutritional Biochemistry, 2023 - Elsevier
Flavonoids are a major group of phytoestrogens associated with physiological effects, and
ecological and social impacts. Although the estrogenic activity of flavonoids was reported by …

Botanicals in postmenopausal osteoporosis

W Słupski, P Jawień, B Nowak - Nutrients, 2021 - mdpi.com
Osteoporosis is a systemic bone disease characterized by reduced bone mass and the
deterioration of bone microarchitecture leading to bone fragility and an increased risk of …

[HTML][HTML] Bioavailability and health benefits of major isoflavone aglycones and their metabolites

YH Hsiao, CT Ho, MH Pan - Journal of Functional Foods, 2020 - Elsevier
Isoflavones are stored in various plants and widely present in different kinds of food in
variable amounts. However, isoflavone aglycones are found less frequently in natural …

Flavonoids in bone erosive diseases: perspectives in osteoporosis treatment

D Bellavia, E Dimarco, V Costa, V Carina… - Trends in Endocrinology …, 2021 - cell.com
Imbalance of bone homeostasis, with excessive bone resorption compared with bone
formation, leads to the development of progressive osteopenia leading to lower bone …

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and …

H Li, Z Tang, P Chu, Y Song, Y Yang, B Sun… - Free Radical Biology …, 2018 - Elsevier
Methylglyoxal (MGO), an active metabolite of glucose, is observed in high levels in the
tissues and blood of diabetic patients. Phosphocreatine (PCr), a high-energy phosphate …

Bioactive scaffolds integrated with liposomal or extracellular vesicles for bone regeneration

M Kang, CS Lee, M Lee - Bioengineering, 2021 - mdpi.com
With population aging and increased life expectancy, an increasing number of people are
facing musculoskeletal health problems that necessitate therapeutic intervention at defect …

[HTML][HTML] Estradiol and estrogen-like alternative therapies in use: The importance of the selective and non-classical actions

S Farkas, A Szabó, AE Hegyi, B Török, CL Fazekas… - Biomedicines, 2022 - mdpi.com
Estrogen is one of the most important female sex hormones, and is indispensable for
reproduction. However, its role is much wider. Among others, due to its neuroprotective …

Isoflavones daidzin and daidzein inhibit lipopolysaccharide-induced inflammation in RAW264. 7 macrophages

Y Tan, X Zhang, WS Cheang - Chinese medicine, 2022 - Springer
Background Inflammation contributes to various diseases and soybeans and legumes are
shown to reduce inflammation. However, the bioactive ingredients involved and …

Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering

SP Soundarya, V Sanjay, AH Menon, S Dhivya… - International journal of …, 2018 - Elsevier
Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable
morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to …