Structural variant calling: the long and the short of it
Recent research into structural variants (SVs) has established their importance to medicine
and molecular biology, elucidating their role in various diseases, regulation of gene …
and molecular biology, elucidating their role in various diseases, regulation of gene …
Structural variation in the sequencing era
Identifying structural variation (SV) is essential for genome interpretation but has been
historically difficult due to limitations inherent to available genome technologies. Detection …
historically difficult due to limitations inherent to available genome technologies. Detection …
A chickpea genetic variation map based on the sequencing of 3,366 genomes
RK Varshney, M Roorkiwal, S Sun, P Bajaj… - Nature, 2021 - nature.com
Zero hunger and good health could be realized by 2030 through effective conservation,
characterization and utilization of germplasm resources. So far, few chickpea (Cicer …
characterization and utilization of germplasm resources. So far, few chickpea (Cicer …
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated …
ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated …
DNA sequencing at 40: past, present and future
This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …
have already witnessed multiple technological revolutions and a growth in scale from a few …
Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9
Targeted insertion of transgenes at pre-determined plant genomic safe harbors provides a
desirable alternative to insertions at random sites achieved through conventional methods …
desirable alternative to insertions at random sites achieved through conventional methods …
Integrative analysis identifies four molecular and clinical subsets in uveal melanoma
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …
Comprehensive evaluation of structural variation detection algorithms for whole genome sequencing
Abstract Background Structural variations (SVs) or copy number variations (CNVs) greatly
impact the functions of the genes encoded in the genome and are responsible for diverse …
impact the functions of the genes encoded in the genome and are responsible for diverse …
[HTML][HTML] Integrated genomic and molecular characterization of cervical cancer
Cancer Genome Atlas Research Network - Nature, 2017 - ncbi.nlm.nih.gov
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Reported here is an extensive molecular characterization of 228 primary cervical cancers …
Reported here is an extensive molecular characterization of 228 primary cervical cancers …
The molecular taxonomy of primary prostate cancer
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …