More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Epidemiological studies have shown a positive relationship between dietary fat intake and
obesity. Since rats and mice show a similar relationship, they are considered an appropriate …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Weight gain induced by an energy-dense diet is hypothesized to arise in part from defects in
the neuronal response to circulating adiposity negative feedback signals, such as insulin …

Obesity, which has developed into a global epidemic, is a risk factor in most chronic
diseases and some forms of malignancy. The discovery of leptin in 1994 has opened a new …

Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

It has been suggested that increased fructose intake is associated with obesity. We
hypothesized that chronic fructose consumption causes leptin resistance, which …

Because the CB1 receptor antagonist SR141716 was previously reported to modulate food
intake in rodents, we studied its efficacy in reducing obesity in a diet-induced obesity (DIO) …

Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …