The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

In recent years, much interest has been generated by the idea that nitrosative stress plays a
role in the aetiology of human diseases, such as atherosclerosis, inflammation, cancer, and …

Beside genetic and life-style characteristics environmental factors may profoundly influence
mortality and life expectancy. The high altitude climate comprises a set of conditions bearing …

Until recently, most of the biological effects of nitric oxide (NO) have been attributed to its
uncharged state (NO), yet NO can also exist in the reduced state as nitroxyl (HNO or NO−) …

Nitroxyl (HNO), the 1-electron reduced and protonated congener of nitric oxide (NO), has
received recent attention as a potential pharmacological agent for the treatment of heart …

Preconditioning refers to a procedure by which a single noxious stimulus below the
threshold of damage is applied to the tissue in order to increase resistance to the same or …

The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …

During acute episodes of hypoxia, chemoreceptor-mediated sympathetic activity increases
heart rate, cardiac output, peripheral resistance and systemic arterial pressure. However …

Increasing data support a connection between obstructive sleep apnea (OSA) and cognitive
impairment but a causal link has yet to be established. Although neuronal loss has been …