Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

We conducted a double-blinded phase I clinical trial to establish whether nicotinamide
adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside …

In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+)
biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

The effect of immunometabolism on age-associated diseases remains uncertain. In this
work, we show that T cells with dysfunctional mitochondria owing to mitochondrial …