Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

In the latest two decades, the interest received by plant proteases has increased
significantly. Plant enzymes such as proteases are widely used in medicine and the food …

The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest
contiguous cluster of protease genes in the human genome, are secreted serine proteases …

Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

Human tissue kallikreins (KLKs or kallikrein-related peptidases) are a subgroup of
extracellular serine proteases that act on a wide variety of physiological substrates, while …

The human kallikrein (KLK)-related peptidases are the largest family of serine peptidases,
comprising 15 members (KLK1–15) and with the majority (KLK4–15) being identified only …

As the outermost layer of the skin, the epidermis is playing a major role in organism
homeostasis providing the first barrier against external aggressions. Although considered as …

Detection of lung cancer at an early stage is necessary for successful therapy and improved
survival rates. We performed a bottom-up proteomics analysis using a two-dimensional LC …

This paper reviews the role of stratum corneum (SC) proteases and their inhibitors in normal
and xerotic skin conditions. The importance of the corneodesmosome for SC integrity is also …