[HTML][HTML] LAG-3 as the third checkpoint inhibitor
V Aggarwal, CJ Workman, DAA Vignali - Nature immunology, 2023 - nature.com
Abstract Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly
expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target, with more …
expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target, with more …
Cutting-edge: Preclinical and clinical development of the first approved lag-3 inhibitor
L Chocarro, A Bocanegra, E Blanco… - Cells, 2022 - mdpi.com
Immune checkpoint inhibitors (ICIs) have revolutionized medical practice in oncology since
the FDA approval of the first ICI 11 years ago. In light of this, Lymphocyte-Activation Gene 3 …
the FDA approval of the first ICI 11 years ago. In light of this, Lymphocyte-Activation Gene 3 …
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation
Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …
Structural basis for mouse LAG3 interactions with the MHC class II molecule IAb
Q Ming, D Antfolk, DA Price, A Manturova… - Nature …, 2024 - nature.com
The immune checkpoint protein, Lymphocyte activation gene-3 (LAG3), binds Major
Histocompatibility Complex Class II (MHC-II) and suppresses T cell activation. Despite the …
Histocompatibility Complex Class II (MHC-II) and suppresses T cell activation. Despite the …
Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function
JL Silberstein, J Du, KW Chan… - Proceedings of the …, 2024 - National Acad Sciences
Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed on activated T
cells and an emerging immunotherapy target. Domain 1 (D1) of LAG-3, which has been …
cells and an emerging immunotherapy target. Domain 1 (D1) of LAG-3, which has been …
Advancement of anti‐LAG‐3 in cancer therapy
Y Li, M Ju, Y Miao, L Zhao, L Xing, M Wei - The FASEB Journal, 2023 - Wiley Online Library
Immune checkpoint inhibitors have effectively transformed the treatment of many cancers,
particularly those highly devastating malignancies. With their widespread popularity, the …
particularly those highly devastating malignancies. With their widespread popularity, the …
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease
S Saevarsdottir, K Bjarnadottir, T Markusson… - Nature …, 2024 - nature.com
Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-
analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are …
analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are …
Lysosome‐targeting bacterial outer membrane vesicles for tumor specific degradation of PD‐L1
P Ji, P Wu, L Wang, Y Wang, X Guo, R Gao, Z Guo… - Small, 2024 - Wiley Online Library
Increased expression of immune check point genes, such as PD‐L1, is one of the main
reasons for immunosuppression, especially for colon cancer. Development of novel …
reasons for immunosuppression, especially for colon cancer. Development of novel …
Prognostic significance of Lymphocyte-activation gene 3 (LAG3) in patients with solid tumors: a systematic review, meta-analysis and pan-cancer analysis
R Li, J Qiu, Z Zhang, C Qu, Z Tang, W Yu, Y Tian… - Cancer Cell …, 2023 - Springer
Background Lymphocyte-activation gene 3 (LAG3) is a recently discovered immune
checkpoint molecule that has been linked to immunosuppression and the advancement of …
checkpoint molecule that has been linked to immunosuppression and the advancement of …
[HTML][HTML] The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy
Lymphocyte activation gene 3 protein (LAG3) is an immune checkpoint receptor that is
highly upregulated on exhausted T cells in the tumor microenvironment. LAG3 transmits …
highly upregulated on exhausted T cells in the tumor microenvironment. LAG3 transmits …