Indole–a promising pharmacophore in recent antiviral drug discovery

A Dorababu - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
The bicyclic molecule indole has been in the limelight because of its numerous
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …

Prospects for developing an hepatitis C virus E1E2‐based nanoparticle vaccine

EA Toth, AK Andrianov… - Reviews in Medical …, 2023 - Wiley Online Library
Globally, more than 58 million people are chronically infected with Hepatitis C virus (HCV)
with 1.5 million new infections occurring each year. An effective vaccine for HCV is therefore …

Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies

GJ Mordecai, L Wilfert, SJ Martin, IM Jones… - The ISME …, 2016 - academic.oup.com
Abstract Treatment of emerging RNA viruses is hampered by the high mutation and
replication rates that enable these viruses to operate as a quasispecies. Declining honey …

[PDF][PDF] Clinical course of infection and viral tissue tropism of hepatitis C virus–like nonprimate hepaciviruses in horses

S Pfaender, JMV Cavalleri, S Walter… - …, 2015 - Wiley Online Library
Hepatitis C virus (HCV) has a very narrow species and tissue tropism and efficiently
replicates only in humans and the chimpanzee. Recently, several studies identified close …

Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches

A Ikram, T Zaheer, FM Awan, A Obaid, A Naz, R Hanif… - Scientific reports, 2018 - nature.com
Hepatitis C virus (HCV) vaccines, designed to augment specific T-cell responses, have been
designated as an important aspect of effective antiviral treatment. However, despite the …

The epidemiology of hepatitis B and hepatitis C infections in China from 2004 to 2014: an observational population‐based study

Z Liu, Q Yang, O Shi, W Ye, X Chen… - Journal of Viral …, 2018 - Wiley Online Library
Viral hepatitis is a major public health concern in China, but data on national
epidemiological characteristics are lacking. We collected reporting incidence data on …

Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective

Z Zhou, J Zhang, E Zhou, C Ren, J Wang… - European Journal of …, 2022 - Elsevier
Hepatitis C virus (HCV) infection has become a global health problem with enormous risks.
Nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) is a component …

Chronic viral hepatitis: policy, regulation, and strategies for its control and elimination in Ethiopia

F Shiferaw, M Letebo, A Bane - BMC Public Health, 2016 - Springer
Abstract Background Hepatitis B and C are silent killers not yet recognized as major public
health challenges in many developing countries with huge disease burden. In Ethiopia …

[HTML][HTML] Exploring HCV genome to construct multi-epitope based subunit vaccine to battle HCV infection: Immunoinformatics based approach

H Khalid, UA Ashfaq - Journal of biomedical informatics, 2020 - Elsevier
Abstract Hepatitis C Virus (HCV) infection is a major cause of chronic liver disease,
hepatocellular carcinoma, and the single most common indication for liver transplantation …

Functional nanomaterials can optimize the efficacy of vaccines

Y Liu, Y Xu, Y Tian, C Chen, C Wang, X Jiang - Small, 2014 - Wiley Online Library
Nanoscale materials can improve the efficacy of vaccines. Herein we review latest
developments that use nanomaterials for vaccines. By highlighting the relationships …