The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens
The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and
its dysfunction has been linked to many neural disorders. However, the molecular, cellular …
its dysfunction has been linked to many neural disorders. However, the molecular, cellular …
A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system
Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating
motivated behaviors, but the circuitry through which they signal positive and negative …
motivated behaviors, but the circuitry through which they signal positive and negative …
Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties
Environmental cues, through Pavlovian learning, become conditioned stimuli that guide
animals toward the acquisition of rewards (for example, food) that are necessary for survival …
animals toward the acquisition of rewards (for example, food) that are necessary for survival …
One is not enough: understanding and modeling polysubstance use
EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
C Soares-Cunha, NAP de Vasconcelos… - Molecular …, 2020 - nature.com
Deficits in decoding rewarding (and aversive) signals are present in several
neuropsychiatric conditions such as depression and addiction, emphasising the importance …
neuropsychiatric conditions such as depression and addiction, emphasising the importance …
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
The persistence of negative affect in pain leads to co-morbid symptoms such as anhedonia
and depression—major health issues in the United States. The neuronal circuitry and …
and depression—major health issues in the United States. The neuronal circuitry and …
[HTML][HTML] The impact of sugar consumption on stress driven, emotional and addictive behaviors
Abstract In 2016 the World Health Organization reported 39% of the world's adult population
(over 18 y) was overweight, with western countries such as Australia and the United States …
(over 18 y) was overweight, with western countries such as Australia and the United States …