Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential
Hepatitis B virus (HBV) infection remains a major public health concern worldwide with
about 257 million individuals chronically infected. Current therapies can effectively control …
about 257 million individuals chronically infected. Current therapies can effectively control …
Epigenetic modulation in chronic hepatitis B virus infection
M Dandri - Seminars in immunopathology, 2020 - Springer
The human hepatitis B virus (HBV) is a small-enveloped DNA virus causing acute and
chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong …
chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong …
Phage-inducible chromosomal minimalist islands (PICMIs), a novel family of small marine satellites of virulent phages
R Barcia-Cruz, D Goudenège… - Nature …, 2024 - nature.com
Phage satellites are bacterial genetic elements that co-opt phage machinery for their own
dissemination. Here we identify a family of satellites, named Phage-Inducible Chromosomal …
dissemination. Here we identify a family of satellites, named Phage-Inducible Chromosomal …
MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut
Bacteriophages play important roles in regulating the intestinal human microbiota
composition, dynamics, and homeostasis, and characterizing their bacterial hosts is needed …
composition, dynamics, and homeostasis, and characterizing their bacterial hosts is needed …
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes
G Giraud, M Rodà, P Huchon, M Michelet… - Nucleic Acids …, 2024 - academic.oup.com
Phase separation regulates fundamental processes in gene expression and is mediated by
the local concentration of proteins and nucleic acids, as well as nucleic acid secondary …
the local concentration of proteins and nucleic acids, as well as nucleic acid secondary …
Viral remodeling of the 4D nucleome
KD Kim, PM Lieberman - Experimental & Molecular Medicine, 2024 - nature.com
The dynamic spatial organization of genomes across time, referred to as the four-
dimensional nucleome (4DN), is a key component of gene regulation and biological fate …
dimensional nucleome (4DN), is a key component of gene regulation and biological fate …
Full-length 5'RACE identifies all major HBV transcripts in HBV-infected hepatocytes and patient serum
B Stadelmayer, A Diederichs, F Chapus, M Rivoire… - Journal of …, 2020 - Elsevier
Background & Aims Covalently closed circular DNA (cccDNA) is the episomal form of the
HBV genome that stably resides in the nucleus of infected hepatocytes. cccDNA is the …
HBV genome that stably resides in the nucleus of infected hepatocytes. cccDNA is the …
A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid
cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin …
cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin …
Transcriptionally inactive hepatitis B virus episome DNA preferentially resides in the vicinity of chromosome 19 in 3D host genome upon infection
The hepatitis B virus (HBV) infects 257 million people worldwide. HBV infection requires
establishment and persistence of covalently closed circular (ccc) DNA, a viral episome, in …
establishment and persistence of covalently closed circular (ccc) DNA, a viral episome, in …
Epstein-Barr virus episome physically interacts with active regions of the host genome in lymphoblastoid cells
ABSTRACT The Epstein-Barr virus (EBV) episome is known to interact with the three-
dimensional structure of the human genome in infected cells. However, the exact locations …
dimensional structure of the human genome in infected cells. However, the exact locations …