Progress toward a vaccine for extraintestinal pathogenic E. coli (ExPEC) II: efficacy of a toxin-autotransporter dual antigen approach

Y Xing, JR Clark, JD Chang, JJ Zulk… - Infection and …, 2024 - Am Soc Microbiol
ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) is a leading cause of
worldwide morbidity and mortality, the top cause of antimicrobial-resistant (AMR) infections …

[HTML][HTML] Intracellular uropathogenic Escherichia coli are undetectable in urinary bladders after oral mecillinam treatment: An experimental study in a pig model of …

K Stærk, RB Grønnemose, Y Palarasah, L Lund… - Microbial …, 2022 - Elsevier
Objectives Experiments in murine models of urinary tract infection (UTI) show that
uropathogenic Escherichia coli (UPEC) form bacterial reservoirs in the bladder tissue that …

Uropathogenic Escherichia coli infection: innate immune disorder, bladder damage, and Tailin Fang II

Z Li, J Li, T Li, Z Song, X Gong - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
Background Uropathogenic Escherichia coli (UPEC) activates innate immune response
upon invading the urinary tract, whereas UPEC can also enter bladder epithelial cells …

Genome‐Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp.

MA Hossain, M Al Amin, MA Khan… - BioMed Research …, 2024 - Wiley Online Library
Shigella stands as a major contributor to bacterial dysentery worldwide scale, particularly in
developing countries with inadequate sanitation and hygiene. The emergence of multidrug …

Evaluation of urine dipstick tests in experimental porcine urinary tract infection with uropathogenic Escherichia coli

K Stærk, LK Jensen, TE Andersen - Scientific Reports, 2023 - nature.com
Urinary tract infection is a common disease in pigs and a major reason for sows to be culled.
The disease, however, is difficult to diagnose due to lack of distinct clinical signs in the …

Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli

H Hirakawa, A Takita, Y Sato, S Hiramoto… - Microbiology …, 2023 - Am Soc Microbiol
Fosfomycin is used to treat a variety of bacterial infections, including urinary tract infections
caused by Escherichia coli. In recent years, quinolone-resistant and extended-spectrum β …

Urinary bladder catheterisation of female pigs: Influence of bladder content and Escherichia coli urinary tract infection on procedural outcome

K Stærk, L Langhorn, B Halle… - Laboratory …, 2024 - journals.sagepub.com
Catheterisation of the urinary bladder is needed in many types of human disease models in
pigs. Based on our extensive experience with the pig as an infection model, we here …

Identification of determinants for entering into a viable but nonculturable state in Vibrio alginolyticus by Tn-seq

J Cai, M Zhou, Y Zhang, Y Ma, Y Zhang… - Applied Microbiology and …, 2023 - Springer
The viable but nonculturable (VBNC) state is a dormant state of nonsporulating bacteria that
enhances survival in adverse environments. Systematic genome-wide research on the …

Genetic requirements for uropathogenic E. coli proliferation in the bladder cell infection cycle

DG Mediati, TA Blair, A Costas, LG Monahan… - bioRxiv, 2023 - biorxiv.org
Uropathogenic Escherichia coli (UPEC) requires an adaptable physiology to survive the
wide range of environments experienced in the host, including gut and urinary tract surfaces …

Progress toward the development of an effective vaccine for Extraintestinal pathogenic E. coli (ExPEC): The application of the multiple-protein subunits vaccine in …

Y Xing, JR Clark, JD Chang, JJ Zulk, DM Chirman… - bioRxiv, 2023 - biorxiv.org
Extraintestinal pathogenic E. coli (ExPEC) is the primary Gram-negative bacterial pathogen,
and the leading cause of life-threatening sepsis and urinary tract infections (UTI) in adults …