Advances in innate immunity over the past decade have revealed distinct classes of pattern
recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular …

The detection of intracellular DNA has emerged to be a key event in the innate immune
response to viruses and intracellular bacteria, and during conditions of sterile inflammation …

The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

AIM2 recognizes foreign dsDNA and assembles into the inflammasome, a filamentous
supramolecular signalling platform required to launch innate immune responses. We show …

Whether host DNA receptors have any capacity to distinguish self from nonself at the
molecular level is an outstanding question in the innate immunity of mammals. Here, by …

Dynamically shifting protein-protein interactions (PPIs) regulate cellular responses to viruses
and the resulting immune signaling. Here, we use thermal proximity coaggregation (TPCA) …

Objective To generate a catalog of citrullinated proteins that are present in the synovia of
patients with rheumatoid arthritis (RA) and to elucidate their relevance for the anti …

The ability to recognize foreign double-stranded (ds) DNA of pathogenic origin in the
intracellular environment is an essential defense mechanism of the human innate immune …

The coevolution of vertebrate and mammalian hosts with DNA viruses has driven the ability
of host cells to distinguish viral from cellular DNA in the nucleus to induce intrinsic immune …