During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

The Sonic hedgehog (SHH) pathway affects neurogenesis and neural patterning during the
development of the central nervous system. Dysregulation of the SHH pathway in the brain …

Hedgehog (Hh) signaling is a classic morphogen in controlling embryonic development and
tissue repairing. Aberrant activation of Hh signaling has been well documented in liver …

Simple Summary Glioblastoma stem cells are a unique population of tumor cells that
contribute to tumor growth, invasion, and resistance to chemotherapy and radiation therapy …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell
growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes …

Basal cell carcinoma (BCC) is one of the most common neoplasms in the population. A good
prognosis and mainly non-aggressive development have made it underdiagnosed and …

Notch and Hedgehog signaling are involved in cancer biology and pathology, including the
maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor …

Pseudo‐natural products (pseudo‐NPs) are de novo combinations of natural product (NP)
fragments that define novel bioactive chemotypes. For their discovery, new design principles …

Abstract The Hedgehog (Hh) signalling pathway plays a critical role in the growth and
patterning during embryonic development and maintenance of adult tissue homeostasis …