Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …

Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Candida albicans is a major human fungal pathogen responsible for both systemic and
mucosal infections in a wide variety of immunocompromised individuals. Because the ability …

The gateway to the secretory pathway is the endoplasmic reticulum (ER), an organelle that
is responsible for the accurate folding, post-translational modification and final assembly of …

Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …

The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …

Unique and evolutionarily conserved signaling pathways allow an organism to sense,
respond to, and adapt to internal and external environmental cues at its biological niche. In …

Rpb4/7 binds RNA polymerase II (RNA Pol II) transcripts co-transcriptionally and
accompanies them throughout their lives. By virtue of its capacity to interact with key …

Gene expression is a complex phenomenon that depends on multiple protein complexes,
including RNA polymerases (RNA pols). In eukaryotes, bacteria, and archaea, RNA pols are …