Burkholderia pseudomallei is a Gram-negative environmental bacterium and the
aetiological agent of melioidosis, a life-threatening infection that is estimated to account …

Classically, the CNS is described as displaying immune privilege, as it shows attenuated
responses to challenge by alloantigen. However, the CNS does show local inflammation in …

Reports indicate an association between COVID-19 and anosmia, as well as the presence
of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium …

The brain is well protected against microbial invasion by cellular barriers, such as the blood-
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …

Abstract Coronavirus disease‐2019 (COVID‐19) was declared a global pandemic on 11
March 2020. Scientists and clinicians must acknowledge that severe acute respiratory …

Infection with Burkholderia pseudomallei can result in asymptomatic seroconversion, a
single skin lesion that may or may not heal spontaneously, a pneumonia which can be …

Cerebral ischemia reperfusion injury (CIRI), one of the major causes of death from stroke in
the world, not only causes tremendous damage to human health, but also brings heavy …

Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central
nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late …

The genus Burkholderia comprises metabolically diverse and adaptable Gram-negative
bacteria, which thrive in often adversarial environments. A few members of the genus are …

The olfactory mucosa is a component of the nasal airway that mediates the sense of smell.
Recent studies point to an important role for the olfactory mucosa as a barrier to both …