Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries
that reduces functional capacity and quality of life of patients. Despite relatively effective …

Background This review aims to highlight mechanistic insights on skeletal muscle
ischemia/reperfusion injury (IRI), a potentially life-threatening complication after acute lower …

Objective Acute limb ischemia (ALI), the most challenging form of ischemia-reperfusion
injury (IRI) in skeletal muscle tissue, leads to decreased skeletal muscle viability and limb …

Dermatomyositis (DM) is an autoimmune disease associated with enhanced type I interferon
(IFN) signalling in skeletal muscle, but the mechanisms underlying muscle dysfunction and …

Consequences of oxidative stress may be beneficial or detrimental in physiological systems.
An organ system's position on the “hormetic curve” is governed by the source and …

Maternal cigarette smoke exposure (SE) during gestation can cause lifelong adverse effects
in the offspring's brain. Several factors may contribute including inflammation, oxidative …

Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in
muscle destruction but also in multi-organ failure and death via systemic effects related to …

Ischemia-reperfusion (I/R) injury is a complication impacting multiple organs and tissues in
clinical conditions ranging from peripheral arterial disease to musculoskeletal trauma and …

Abstract Silent information regulator 6 (SIRT6), a class III histone deacetylase, has been
revealed to participate in multiple metabolic processes in the liver, and it plays important …

Exercise can alter the skeletal muscle DNA methylome, yet little is known about the role of
the DNA methylation machinery in exercise capacity. Here, we show that DNMT3A …