The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Growing muscle tissue in culture from animal stem cells to produce meat theoretically
eliminates the need to sacrifice animals. So-called “cultured” or “synthetic” or “in vitro” meat …

Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer–
associated genes is highly prevalent in the normal population. Its etiology, biological impact …

Background—Aging and aging-related disorders impair the survival and differentiation
potential of bone marrow mesenchymal stem cells (MSCs) and limit their therapeutic …

Osteoarthritis is a degenerative disease of joints with destruction of articular cartilage
associated with subchondral bone hypertrophy and inflammation. OA is the leading cause of …

Transplantation of mesenchymal stem cells (MSCs) holds great promise in the repair of
cigarette smoke (CS)-induced lung damage in chronic obstructive pulmonary disease …

Stem cells are primitive cells found in many multicellular organisms. Self-renewal and
differentiation potency are two defining properties of stem cells. Self-renewal is the ability to …

Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells
(MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know …

Adult stem cell therapies have provided success for more than 50 years, through
reconstitution of the hematopoietic system using bone marrow, umbilical cord blood, and …

Background: Chondral lesions in athletically active patients cause considerable morbidity,
and treatment with existing cell-based therapies can be challenging. Bone marrow has been …