Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of
spine synapses receiving excitatory input. Synaptic signals not only act locally but are also …

The trafficking chaperone PDE6D (or PDEδ) was proposed as a surrogate target for K-Ras,
leading to the development of a series of inhibitors that block its prenyl binding pocket …

The 534 protein kinases encoded in the human genome constitute a large druggable class
of proteins that include both well-studied and understudied “dark” members. Accurate …

The trafficking chaperone PDE6D (or PDEδ) was proposed as a surrogate target for K-Ras,
leading to the development of a series of inhibitors that block its prenyl-binding pocket …

Abstract Type II diabetes (T2D) is a disease that is characterized by insulin resistance,
hyperglycemia, and impaired insulin secretion via pancreatic b-cells. In skeletal muscle and …