Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Affinity chromatography: A review of trends and developments over the past 50 years

EL Rodriguez, S Poddar, S Iftekhar, K Suh… - … of Chromatography B, 2020 - Elsevier
The field of affinity chromatography, which employs a biologically-related agent as the
stationary phase, has seen significant growth since the modern era of this method began in …

Single cell isolation and analysis

P Hu, W Zhang, H Xin, G Deng - Frontiers in cell and developmental …, 2016 - frontiersin.org
Individual cell heterogeneity within a population can be critical to its peculiar function and
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …

Rare cell isolation and analysis in microfluidics

Y Chen, P Li, PH Huang, Y Xie, JD Mai, L Wang… - Lab on a Chip, 2014 - pubs.rsc.org
Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

Microfluidic blood cell sorting: now and beyond

ZTF Yu, KM Aw Yong, J Fu - Small, 2014 - Wiley Online Library
Blood plays an important role in homeostatic regulation with each of its cellular components
having important therapeutic and diagnostic uses. Therefore, separation and sorting of …

Past, present, and future of affinity-based cell separation technologies

K Bacon, A Lavoie, BM Rao, M Daniele, S Menegatti - Acta biomaterialia, 2020 - Elsevier
Progress in cell purification technology is critical to increase the availability of viable cells for
therapeutic, diagnostic, and research applications. A variety of techniques are now available …

Single-cell proteomics with spatial attributes: tools and techniques

V Lohani, A AR, S Kundu, MDQ Akhter, S Bag - ACS omega, 2023 - ACS Publications
Now-a-days, the single-cell proteomics (SCP) concept is attracting interest, especially in
clinical research, because it can identify the proteomic signature specific to diseased cells …

On-chip integrated optical stretching and electrorotation enabling single-cell biophysical analysis

L Huang, F Liang, Y Feng, P Zhao… - Microsystems & …, 2020 - nature.com
Cells have different intrinsic markers such as mechanical and electrical properties, which
may be used as specific characteristics. Here, we present a microfluidic chip configured with …

Negative enrichment of circulating tumor cells using a geometrically activated surface interaction chip

KA Hyun, TY Lee, HI Jung - Analytical chemistry, 2013 - ACS Publications
Circulating tumor cells (CTCs) have attracted a great deal of attention, as they can be
exploited to investigate metastasis. The molecular and cellular characteristics of these cells …

Recent advances in microfluidic cell separations

Y Gao, W Li, D Pappas - Analyst, 2013 - pubs.rsc.org
The isolation and sorting of cells has become an increasingly important step in chemical and
biological analyses. As a unit operation in more complex analyses, isolating a …