With the 2019 breakthrough in the development of highly effective modulator therapy
providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …

Introduction: Pseudomonas aeruginosa is the most commonly isolated pathogen in
bronchiectasis and is associated with worse outcomes. Eradication treatment is …

Background Cystic fibrosis (CF) is a genetic disorder causing poor mucociliary clearance in
the airways and subsequent respiratory infection. The recently approved triple therapy …

Rationale: Pulmonary exacerbations (PEx) remain the most common cause of morbidity,
recurrent hospitalization, and diminished survival in people with cystic fibrosis (PWCF) and …

The dense O-glycosylation of mucins plays an important role in the defensive properties of
the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and …

The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense
when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such …

Rationale: Pharmacological improvement of CFTR function with elexacaftor/tezacaftor/
ivacaftor (ETI) provides unprecedented improvements in lung function and other clinical …

Extract In people with cystic fibrosis (CF), CF transmembrane conductance regulator (CFTR)
protein dysfunction in the lower airways results in dehydrated airway secretions and …

Background This study sought to evaluate the impact of elexacaftor/tezacaftor/ivacaftor (ETI)
on lung structural abnormalities in adults with cystic fibrosis (awCF) with a specific focus on …

The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the
antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against …