I. Overview T HE general characterization of the growth hormone/insulin-like growth factor-I
(GH/IGF-I) system has been established for a considerable length of time, and we will not …

Some of the most serious consequences of ageing are its effects on skeletal muscle. The
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …

In several species, including humans, the dentate granule cell layer (GCL) of the
hippocampus exhibits neurogenesis throughout adult life. The ability to regulate adult …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

Purpose: The purpose of this study was to examine the impact of exercise-induced
metabolic stress on hormonal responses and chronic muscular adaptations. Methods: We …

Osteoporosis is a serious health problem that diminishes quality of life and levies a financial
burden on those who fear and experience bone fractures. Physical activity as a way to …

Human growth hormone (hGH) is secreted in a pulsatile fashion, generally following a
circadian rhythm. A number of physiological stimuli can initiate hGH secretion, the most …

Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …

We have examined the mechanisms underlying reduced circulating GH concentrations in
the obese human. Computer-assisted (deconvolution) analysis was used to determine …

A chemiluminescence-based GH assay with 30-to 100-fold increased sensitivity recently
disclosed combined basal and pulsatile GH secretion in men. However, how age, sex …