Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …

Objective An international meeting was organised to develop consensus on (1) the
landmarks to define the gastro-oesophageal junction (GOJ),(2) the occurrence and …

The care of patients with oesophageal cancer or of individuals who have an elevated risk of
oesophageal cancer has changed dramatically. The epidemiology of squamous cell and …

Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …

The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention. Here we model occult preneoplasia by …

Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose
individuals to cancer development lines a portion of the distal oesophagus, is the only …

The accurate, rapid, and sensitive identification of cancer cells in complex physiological
environments is significant in biological studies, personalized medicine, and biomedical …