Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Q Zeng, M Mousa, AS Nadukkandy, L Franssens… - Nature Reviews …, 2023 - nature.com
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
E Madissoon, AJ Oliver, V Kleshchevnikov… - Nature Genetics, 2023 - nature.com
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …
Single-cell RNA sequencing unifies developmental programs of esophageal and gastric intestinal metaplasia
K Nowicki-Osuch, L Zhuang, TS Cheung, EL Black… - Cancer discovery, 2023 - AACR
Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction
K Sugano, SJ Spechler, EM El-Omar, KEL McColl… - Gut, 2022 - gut.bmj.com
Objective An international meeting was organised to develop consensus on (1) the
landmarks to define the gastro-oesophageal junction (GOJ),(2) the occurrence and …
landmarks to define the gastro-oesophageal junction (GOJ),(2) the occurrence and …
Improving outcomes in patients with oesophageal cancer
The care of patients with oesophageal cancer or of individuals who have an elevated risk of
oesophageal cancer has changed dramatically. The epidemiology of squamous cell and …
oesophageal cancer has changed dramatically. The epidemiology of squamous cell and …
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
[HTML][HTML] Deterministic evolution and stringent selection during preneoplasia
The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention. Here we model occult preneoplasia by …
clues to malignancy detection and prevention. Here we model occult preneoplasia by …
Mechanisms and pathophysiology of Barrett oesophagus
RF Souza, SJ Spechler - Nature Reviews Gastroenterology & …, 2022 - nature.com
Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose
individuals to cancer development lines a portion of the distal oesophagus, is the only …
individuals to cancer development lines a portion of the distal oesophagus, is the only …
FINDER: A Fluidly Confined CRISPR‐Based DNA Reporter on Living Cell Membranes for Rapid and Sensitive Cancer Cell Identification
Y Yin, W Xie, M Xiong, Y Gao, Q Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
The accurate, rapid, and sensitive identification of cancer cells in complex physiological
environments is significant in biological studies, personalized medicine, and biomedical …
environments is significant in biological studies, personalized medicine, and biomedical …