Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Bone development and bone remodelling during adult life are highly anabolic processes
requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone …

Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival
rate. There is a critical need to find new multiple myeloma vulnerabilities and therapeutic …

Metabolic reprogramming, fundamentally pivotal in carcinogenesis and progression of
cancer, is considered as a promising therapeutic target against tumors. In chronic …

Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled
proliferation of plasma cells in the bone marrow. MM patients with aggressive progression …

Fatty acids (FAs) are critical nutrients that regulate an organism's health and development in
mammal. Long-chain fatty acids (LCFAs) can be divided into saturated and unsaturated fatty …

Obesity and obesogenic behaviors are positively associated with both monoclonal
gammopathy of unknown significance (MGUS) and multiple myeloma (MM). As the only …

Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the
bone marrow. Multiple myeloma cells are characterized by distinctive biological features that …

Cancer is closely related to lipid metabolism, with the tumor microenvironment (TME)
containing numerous lipid metabolic interactions. Cancer cells can bidirectionally interact …