Inhibitors of nuclear transport

DA Jans, AJ Martin, KM Wagstaff - Current opinion in cell biology, 2019 - Elsevier
Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

KA Gajewska, H Lescesen, M Ramialison… - Nature …, 2021 - nature.com
The importin superfamily member Importin-13 is a bidirectional nuclear transporter. To
delineate its functional roles, we performed transcriptomic analysis on wild-type and Importin …

Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse

Y Miyamoto, M Sasaki, H Miyata, Y Monobe… - The FASEB …, 2020 - Wiley Online Library
Importin α proteins play a central role in the transport of cargo from the cytoplasm to the
nucleus. In this study, we observed that male knock‐out mice for importin α4, which is …

Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons

JM Bin, D Suminaite, SK Benito-Kwiecinski… - Nature …, 2024 - nature.com
Axon diameter influences the conduction properties of myelinated axons, both directly, and
indirectly through effects on myelin. However, we have limited understanding of …

Extensive identification and in-depth validation of importin 13 cargoes

I Baade, C Spillner, K Schmitt, O Valerius… - Molecular & Cellular …, 2018 - ASBMB
Importin 13 is a member of the importin β family of transport receptors. Unlike most family
members, importin 13 mediates both, nuclear protein import and export. To search for novel …

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

S Zhang, NA Williamson, L Duvick, A Lee… - Nature …, 2020 - nature.com
The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in
spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear …

Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation

KA Gajewska, JM Haynes, DA Jans - Cells, 2022 - mdpi.com
Molecular transport between the nucleus and cytoplasm of the cell is mediated by the
importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 …

The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation

S Fatima, KM Wagstaff, SM Lim, JM Polo… - Biochemical and …, 2021 - Elsevier
Abstract Nuclear transporter Importin (Imp, Ipo) 13 is known to transport various mammalian
cargoes into/out of the nucleus, but its role in directing cell-fate is unclear. Here we examine …

The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis

KA Gajewska, DA Jans, KM Wagstaff - Cells, 2023 - mdpi.com
The cellular response to environmental stresses, such as heat and oxidative stress, is
dependent on extensive trafficking of stress-signalling molecules between the cytoplasm …

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function

X Liu, W Lin, X Shi, RG Davies, KM Wagstaff… - Biochemical …, 2018 - portlandpress.com
Importin 13 (IPO13) is a key member of the importin β superfamily, which can transport
cargoes both into and out of the nucleus to contribute to a variety of important cellular …