Inhibitors of nuclear transport
DA Jans, AJ Martin, KM Wagstaff - Current opinion in cell biology, 2019 - Elsevier
Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …
Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response
KA Gajewska, H Lescesen, M Ramialison… - Nature …, 2021 - nature.com
The importin superfamily member Importin-13 is a bidirectional nuclear transporter. To
delineate its functional roles, we performed transcriptomic analysis on wild-type and Importin …
delineate its functional roles, we performed transcriptomic analysis on wild-type and Importin …
Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse
Y Miyamoto, M Sasaki, H Miyata, Y Monobe… - The FASEB …, 2020 - Wiley Online Library
Importin α proteins play a central role in the transport of cargo from the cytoplasm to the
nucleus. In this study, we observed that male knock‐out mice for importin α4, which is …
nucleus. In this study, we observed that male knock‐out mice for importin α4, which is …
Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons
JM Bin, D Suminaite, SK Benito-Kwiecinski… - Nature …, 2024 - nature.com
Axon diameter influences the conduction properties of myelinated axons, both directly, and
indirectly through effects on myelin. However, we have limited understanding of …
indirectly through effects on myelin. However, we have limited understanding of …
Extensive identification and in-depth validation of importin 13 cargoes
I Baade, C Spillner, K Schmitt, O Valerius… - Molecular & Cellular …, 2018 - ASBMB
Importin 13 is a member of the importin β family of transport receptors. Unlike most family
members, importin 13 mediates both, nuclear protein import and export. To search for novel …
members, importin 13 mediates both, nuclear protein import and export. To search for novel …
The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways
S Zhang, NA Williamson, L Duvick, A Lee… - Nature …, 2020 - nature.com
The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in
spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear …
spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear …
Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation
Molecular transport between the nucleus and cytoplasm of the cell is mediated by the
importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 …
importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 …
The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation
Abstract Nuclear transporter Importin (Imp, Ipo) 13 is known to transport various mammalian
cargoes into/out of the nucleus, but its role in directing cell-fate is unclear. Here we examine …
cargoes into/out of the nucleus, but its role in directing cell-fate is unclear. Here we examine …
The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis
KA Gajewska, DA Jans, KM Wagstaff - Cells, 2023 - mdpi.com
The cellular response to environmental stresses, such as heat and oxidative stress, is
dependent on extensive trafficking of stress-signalling molecules between the cytoplasm …
dependent on extensive trafficking of stress-signalling molecules between the cytoplasm …
PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function
X Liu, W Lin, X Shi, RG Davies, KM Wagstaff… - Biochemical …, 2018 - portlandpress.com
Importin 13 (IPO13) is a key member of the importin β superfamily, which can transport
cargoes both into and out of the nucleus to contribute to a variety of important cellular …
cargoes both into and out of the nucleus to contribute to a variety of important cellular …