Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure

M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

NP Daskalakis, RC Bagot, KJ Parker… - …, 2013 - Elsevier
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …

Annual research review: The neurobiology and physiology of resilience and adaptation across the life course

IN Karatsoreos, BS McEwen - Journal of Child Psychology and …, 2013 - Wiley Online Library
Background Adaptation is key to survival. An organism must adapt to environmental
challenges in order to be able to thrive in the environment in which they find themselves …

Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?

J Lehmann, J Feldon - Reviews in the Neurosciences, 2000 - degruyter.com
Over the last decades of research there has been increasing interest in endocrine and
behavioral effects of postnatal environmental manipulations. A manipulation procedure that …

Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats

A Wigger, ID Neumann - Physiology & behavior, 1999 - Elsevier
There is evidence that stressful events during the neonatal “stress hyporesponsive period”
may influence both emotional behavior and the maturation of the hypothalamic–pituitary …

HPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressors

CM McCormick, IZ Mathews - Pharmacology Biochemistry and Behavior, 2007 - Elsevier
The hypothalamic–pituitary–adrenal (HPA) axis is one of the physiological systems involved
in coping with stressors. There are functional shifts in the HPA axis and its regulation by sex …

Long-term effects of early-life environmental manipulations in rodents and primates: potential animal models in depression research

CR Pryce, D Rüedi-Bettschen, AC Dettling… - Neuroscience & …, 2005 - Elsevier
Depression is one of the most common human illnesses and is of immense clinical and
economic significance. Knowledge of the neuro-psychology,-biology and-pharmacology of …

Stress, genes and the mechanism of programming the brain for later life

ER De Kloet, RM Sibug, FM Helmerhorst… - … & Biobehavioral Reviews, 2005 - Elsevier
de Kloet ER, Sibug RM, Helmerhost FM, Schmidt M. Stress, genes and the mechanism of
programming the brain for later life. Neurosci Biobehav Rev XXX–XXX, 2005 adverse …

The effects of neonatal handling on the development of the adrenocortical response to stress: implications for neuropathology and cognitive deficits in later life

MJ Meaney, JB Mitchell, DH Aitken, S Bhatnagar… - …, 1991 - Elsevier
Several years ago Levine, Denenberg, Weininger, Ader, and others described the effects of
postnatal “handling” on the development of behavioral and endocrine responses to stress …

The development and neurobiology of infant attachment and fear

MS Landers, RM Sullivan - Developmental neuroscience, 2012 - karger.com
Survival of altricial infants depends on attachment to the caregiver–a process that requires
infants to identify, learn, remember, and approach their attachment figure. Here we review …