Short and efficient synthesis of heterocyclic compounds are highly desirable in synthetic
organic chemistry. It is a dream approach to accomplish these syntheses from readily …

Motivation Comparative analysis of homologous proteins in a functionally diverse
superfamily is a valuable tool at studying structure-function relationship, but represents a …

Local 3D-structural differences in homologous proteins contribute to functional diversity
observed in a superfamily, but so far received little attention as bioinformatic analysis was …

Background Due to the importance of both prostaglandins (PGs) and leukotrienes (LTs) as
pro-inflammatory mediators, and the potential for eicosanoid shunting in the presence of …

In recent years, the phenomenon of allostery has witnessed growing attention driven by a
fundamental interest in new ways to regulate the functional properties of proteins, as well as …

Life expectancy is growing especially in developed countries. In this regard, aging-
associated diseases such as Alzheimer's disease (AD) are more common. Multi …

В последние годы все большее внимание уделяется явлению аллостерии. Это
обусловлено как фундаментальным интересом к поиску новых путей регуляции …