Despite the high number of drug-discovery programs dedicated to finding small-molecule
MCH-R1 antagonists for the treatment of obesity and/or mood disorders, a very limited …

A series of new N-[(benzo) thiazol-2-yl]-2/3-[3, 4-dihydroisoquinolin-2 (1H)-yl]
ethan/propanamide derivatives was synthesized and characterized by 1 H, 13 C NMR and …

The melanin-concentrating hormone (MCH) is a hypothalamic peptide that binds to one of
two receptors: MCH1 and MCH2. MCH1 is well-recognized for its orexigenic properties but …

The 5-HT2C receptor has emerged as a promising target in the treatment of a variety of
central nervous system disorders. We have first identified aporphines as a new class of 5 …

Despite remarkable progress in the elucidation of energy balance and regulation, the
development of new antiobesity drugs is still at the stage of infancy. Herein we briefly …

There is compelling genetic and pharmacologic evidence to indicate that melanin-
concentrating hormone receptor-1 (MCHR1) signaling is involved in the regulation of food …

4,145,427 A 3/1979 Langbein et al.(() p 5,028,519 A 7/1991 Morigaki et al. 5,688,960 A
11/1997 Shankar N 5,696,267 A 12/1997 Reichard et al. V 5,723,490 A 3/1998 Tung Z …

Melanin concentrating hormone (MCH) is a cyclic, nonadecapeptide expressed in the CNS
of all vertebrates that regulates feeding behavior and energy homeostasis. The MCH-1 …

This review discusses the biological activity and synthesis of 1, 9-diazaspiro [5.5]
undecanes, including those ring-fused with arenes and heteroarenes and/or containing a …

The invention relates to pyrrolidinyl, piperidinyl, and hexahy droaZepinyl compounds of
Formula I: and pharmaceutically acceptable salts, prodrugs, or solvates thereof, Wherein R1 …