[HTML][HTML] In silico modelling of cancer nanomedicine, across scales and transport barriers
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
Implementing vertex dynamics models of cell populations in biology within a consistent computational framework
The dynamic behaviour of epithelial cell sheets plays a central role during development,
growth, disease and wound healing. These processes occur as a result of cell adhesion …
growth, disease and wound healing. These processes occur as a result of cell adhesion …
[HTML][HTML] Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …
due to their ability to augment experimental and clinical investigations. Cardiac …
Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …
various cardiac diseases, which remain the most common cause of death in the developed …
[HTML][HTML] Chaste: an open source C++ library for computational physiology and biology
Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …
the computational simulation of mathematical models developed for physiology and biology …
[HTML][HTML] Comparing individual-based approaches to modelling the self-organization of multicellular tissues
The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …
renewal. Cells react to their microenvironment by modulating processes such as movement …
Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology
OJ Britton, A Bueno-Orovio… - Proceedings of the …, 2013 - National Acad Sciences
Cellular and ionic causes of variability in the electrophysiological activity of hearts from
individuals of the same species are unknown. However, improved understanding of this …
individuals of the same species are unknown. However, improved understanding of this …
Verification of cardiac tissue electrophysiology simulators using an N-version benchmark
Ongoing developments in cardiac modelling have resulted, in particular, in the development
of advanced and increasingly complex computational frameworks for simulating cardiac …
of advanced and increasingly complex computational frameworks for simulating cardiac …
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
GR Mirams, Y Cui, A Sher, M Fink… - Cardiovascular …, 2011 - academic.oup.com
Aims The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one
of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de …
of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de …
[HTML][HTML] Mathematical modelling reveals cellular dynamics within tumour spheroids
Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and
response to treatment of different cancer cell lines. Their popularity is largely due to the …
response to treatment of different cancer cell lines. Their popularity is largely due to the …