Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

P Meier, AJ Legrand, D Adam, J Silke - Nature Reviews Cancer, 2024 - nature.com
Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Antigen cross-presentation by macrophages

EM Muntjewerff, LD Meesters… - Frontiers in …, 2020 - frontiersin.org
The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T
lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has …

Regulation of immune responses by mTOR

JD Powell, KN Pollizzi, EB Heikamp… - Annual review of …, 2012 - annualreviews.org
mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …

Inflammatory bowel disease: cause and immunobiology

DC Baumgart, SR Carding - The Lancet, 2007 - thelancet.com
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …

Tolerogenic dendritic cells

RM Steinman, D Hawiger… - Annual review of …, 2003 - annualreviews.org
▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In
addition, there is increasing evidence that DCs in situ induce antigen-specific …

Lentivirus-delivered stable gene silencing by RNAi in primary cells

SA Stewart, DM Dykxhoorn, D Palliser, H Mizuno… - Rna, 2003 - rnajournal.cshlp.org
Genome-wide genetic approaches have proven useful for examining pathways of biological
significance in model organisms such as Saccharomyces cerevisiae, Drosophila …

Dendritic cells as gatekeepers of tolerance

A Waisman, D Lukas, BE Clausen, N Yogev - Seminars in …, 2017 - Springer
Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune
responses. In particular, they are considered as the most potent antigen presenting cells …

[HTML][HTML] Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

S Nagaraj, K Gupta, V Pisarev, L Kinarsky… - Nature medicine, 2007 - nature.com
Abstract Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor
cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we …

[HTML][HTML] Homing and cellular traffic in lymph nodes

UH von Andrian, TR Mempel - Nature Reviews Immunology, 2003 - nature.com
Lymph nodes (LNs) are the organs where innate immune responses lead to acquired
immunity, where some of our most devastating pathogens evade immunity, and where …

[HTML][HTML] Modulation of tryptophan catabolism by regulatory T cells

F Fallarino, U Grohmann, KW Hwang, C Orabona… - Nature …, 2003 - nature.com
Regulatory T (TR) cells manifest constitutive expression of cytotoxic T lymphocyte–
associated antigen 4 (CTLA-4), but the function of CTLA-4 in mediating the regulatory …