Clinical applications of chemical exchange saturation transfer (CEST) MRI

KM Jones, AC Pollard, MD Pagel - Journal of Magnetic …, 2018 - Wiley Online Library
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
been developed and employed in multiple clinical imaging research centers worldwide …

Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods

M Zaiss, P Bachert - Physics in Medicine & Biology, 2013 - iopscience.iop.org
Chemical exchange saturation transfer (CEST) of metabolite protons that undergo exchange
processes with the abundant water pool enables a specific contrast for magnetic resonance …

Inverse Z‐spectrum analysis for spillover‐, MT‐, and T1‐corrected steady‐state pulsed CEST‐MRI – application to pH‐weighted MRI of acute stroke

M Zaiss, J Xu, S Goerke, IS Khan, RJ Singer… - NMR in …, 2014 - Wiley Online Library
Endogenous chemical exchange saturation transfer (CEST) effects are always diluted by
competing effects, such as direct water proton saturation (spillover) and semi‐solid …

Alternatives to gadolinium-based metal chelates for magnetic resonance imaging

S Viswanathan, Z Kovacs, KN Green… - Chemical …, 2010 - ACS Publications
Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical
imaging over the last few decades owing to its exceptional spatial and anatomical …

Nuts and bolts of chemical exchange saturation transfer MRI

G Liu, X Song, KWY Chan… - NMR in Biomedicine, 2013 - Wiley Online Library
Chemical exchange saturation transfer (CEST) has emerged as a novel MRI contrast
mechanism that is well suited for molecular imaging studies. This new mechanism can be …

Relaxation-compensated CEST-MRI of the human brain at 7 T: unbiased insight into NOE and amide signal changes in human glioblastoma

M Zaiss, J Windschuh, D Paech, JE Meissner, S Burth… - Neuroimage, 2015 - Elsevier
Endogenous chemical exchange saturation transfer (CEST) effects of protons resonating
near to water protons are always diluted by competing effects such as direct water saturation …

Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra

M Zaiß, B Schmitt, P Bachert - Journal of magnetic resonance, 2011 - Elsevier
Chemical exchange saturation transfer (CEST) processes in aqueous systems are
quantified by evaluation of z-spectra, which are obtained by acquisition of the water proton …

Chemical exchange saturation transfer imaging and spectroscopy

J Zhou, PCM van Zijl - Progress in Nuclear Magnetic Resonance …, 2006 - Elsevier
The study of chemical exchange processes is one of the oldest and still most vigorously
investigated topics in NMR spectroscopy. The effects of chemical exchange on the NMR …

MR imaging of the amide‐proton transfer effect and the pH‐insensitive nuclear Overhauser effect at 9.4 T

T Jin, P Wang, X Zong, SG Kim - Magnetic resonance in …, 2013 - Wiley Online Library
The amide proton transfer (APT) effect has emerged as a unique endogenous molecular
imaging contrast mechanism with great clinical potentials. However, in vivo quantitative …

A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with Iobitridol

DL Longo, PZ Sun, L Consolino… - Journal of the …, 2014 - ACS Publications
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic
resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are …