Cyclohexane-1, 3-dione derivatives as future therapeutic agents for NSCLC: QSAR modeling, in silico ADME-Tox properties, and structure-based drug designing …
The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …
Natural active ingredients and TRPV1 modulation: focus on key chemical moieties involved in ligand–target interaction
Diseases such as cancer, neurological pathologies and chronic pain represent currently
unmet needs. The existing pharmacotherapeutic options available for treating these …
unmet needs. The existing pharmacotherapeutic options available for treating these …
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity
GR Velma, Z Shen, C Holberg, J Fu… - Journal of Medicinal …, 2024 - ACS Publications
The SARS-CoV-2 papain-like protease (PLpro), essential for viral processing and immune
response disruption, is a promising target for treating acute infection of SARS-CoV-2. To …
response disruption, is a promising target for treating acute infection of SARS-CoV-2. To …
Regulation of Tumor Apoptosis of Poriae cutis-Derived Lanostane Triterpenes by AKT/PI3K and MAPK Signaling Pathways In Vitro
S Yue, X Feng, Y Cai, SA Ibrahim, Y Liu, W Huang - Nutrients, 2023 - mdpi.com
Poria cocos is traditionally used as both food and medicine. Triterpenoids in Poria cocos
have a wide range of pharmacological activities, such as diuretic, sedative and tonic …
have a wide range of pharmacological activities, such as diuretic, sedative and tonic …
Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2, 4-thiazolidinediones as partial PPAR-γ agonists
Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also
termed as selective PPAR-γ modulators, are more beneficial than full agonists because they …
termed as selective PPAR-γ modulators, are more beneficial than full agonists because they …
[PDF][PDF] Nit, ulescu, GM; Olaru, OT; Negres, S
C Andrei, A Zanfirescu - … and TRPV1 Modulation: Focus on Key …, 2023 - academia.edu
Diseases such as cancer, neurological pathologies and chronic pain represent currently
unmet needs. The existing pharmacotherapeutic options available for treating these …
unmet needs. The existing pharmacotherapeutic options available for treating these …
Structure-based virtual screening and molecular docking approaches to identify potential inhibitors against KIF2C to combat glioma
Glioma, a kind of malignant brain tumor, is extremely lethal. Kinesin family member 2C
(KIF2C) was found to have an aberrant expression in several cancer types, including lung …
(KIF2C) was found to have an aberrant expression in several cancer types, including lung …
Mechanistic insight of Staphylococcus aureus associated skin cancer in humans by Santalum album derived phytochemicals: an extensive computational and …
An excessive amount of multidrug-resistant Staphylococcus aureus is commonly associated
with actinic keratosis (AK) and squamous cell carcinoma (SCC) by secreted virulence …
with actinic keratosis (AK) and squamous cell carcinoma (SCC) by secreted virulence …
Computer-aided drug design of novel nirmatrelvir analogs inhibiting main protease of Coronavirus SARS-CoV-2
KO Lohachova, AS Sviatenko… - Journal of Applied …, 2024 - japsonline.com
A computer-aided drug design of new derivatives of nirmatrelvir, an orally active inhibitor of
the main-protease (Mpro) of the severe acute respiratory syndrome Coronavirus 2 (SARS …
the main-protease (Mpro) of the severe acute respiratory syndrome Coronavirus 2 (SARS …
Hybrid Virtual Screening Approach to Predict Novel Natural Compounds against HIV-1 CCR5
AM Eid, A Selim, M Khaled… - The Journal of Physical …, 2024 - ACS Publications
Background: Human immunodeficiency virus (HIV) infection continues to pose a major
global health challenge. HIV entry into host cells via membrane fusion mediated by the viral …
global health challenge. HIV entry into host cells via membrane fusion mediated by the viral …