Tissue sodium accumulation induces organ inflammation and injury in chronic kidney disease

Y Ito, T Sun, H Tanaka, M Yamaguchi… - International Journal of …, 2023 - mdpi.com
High salt intake is a primary cause of over-hydration in chronic kidney disease (CKD)
patients. Inflammatory markers are predictors of CKD mortality; however, the pathogenesis …

Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of …

FJ Charchar, PR Prestes, C Mills, SM Ching… - Journal of …, 2024 - journals.lww.com
Hypertension, defined as persistently elevated systolic blood pressure (SBP)> 140 mmHg
and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of …

Does excess tissue sodium storage regulate blood pressure?

G Rossitto, C Delles - Current Hypertension Reports, 2022 - Springer
Abstract Purpose of Review The regulation of blood pressure is conventionally
conceptualised into the product of “circulating blood volume” and “vasoconstriction …

[HTML][HTML] Novel mechanisms of salt-sensitive hypertension

L Vogt, FZ Marques, T Fujita, EJ Hoorn, AHJ Danser - Kidney International, 2023 - Elsevier
A high dietary sodium-consumption level is considered the most important lifestyle factor that
can be modified to help prevent an increase in blood pressure and the development of …

Clinical impact of tissue sodium storage

RHG Olde Engberink, V Selvarajah, L Vogt - Pediatric Nephrology, 2020 - Springer
In recent times, the traditional nephrocentric, two-compartment model of body sodium has
been challenged by long-term sodium balance studies and experimental work on the dermal …

Effects of polygenic risk score and sodium and potassium intake on hypertension in Asians: A nationwide prospective cohort study

B Eunjin, Y Ji, J Jo, Y Kim, JP Lee, S Won… - Hypertension Research, 2024 - nature.com
Genetic factors, lifestyle, and diet have been shown to play important roles in the
development of hypertension. Increased salt intake is an important risk factor for …

Tangram of Sodium and Fluid Balance

D Bagordo, GP Rossi, C Delles, H Wiig, G Rossitto - Hypertension, 2024 - Am Heart Assoc
Homeostasis of fluid and electrolytes is a tightly controlled physiological process. Failure of
this process is a hallmark of hypertension, chronic kidney disease, heart failure, and other …

Mechanisms of sodium‐mediated injury in cardiovascular disease: old play, new scripts

G Rossitto, C Delles - The FEBS Journal, 2022 - Wiley Online Library
There is a strong association between salt intake and cardiovascular diseases, particularly
hypertension, on the population level. The mechanisms that explain this association remain …

Body fluids in end-stage renal disease: statics and dynamics

JP Kooman, FM van der Sande - Blood purification, 2019 - karger.com
Background: Abnormalities in fluid status in hemodialysis (HD) patients are highly prevalent
and are related to adverse outcomes. Summary: The inherent discontinuity of the HD …

From salt to hypertension, what is missed?

Z Ma, SL Hummel, N Sun… - The Journal of Clinical …, 2021 - Wiley Online Library
Excess salt intake is viewed as a major contributor to hypertension and cardiovascular
disease, and dietary salt restriction is broadly recommended by public health guidelines …