Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Abstract G-quadruplexes (G4s) are nucleic acid secondary structures that form within
guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Human telomeric G‐quadruplex DNA structures are attractive anticancer drug targets, but
the target's polymorphism complicates the drug design: different ligands prefer different …

G-quadruplexes are guanine-rich nucleic acids that fold by forming successive quartets of
guanines (the G-tetrads), stabilized by intra-quartet hydrogen bonds, inter-quartet stacking …

G-quadruplexes adopt various folding topologies, but information on their folding pathways
remains scarce. Here, we used electrospray mass spectrometry to detect and quantify the …

Abstract G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich
sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

Designing ligands targeting G-quadruplex nucleic acid structures and affecting cellular
processes is complicated because there are multiple target sequences and some are …