Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Rationale: Regression of atherosclerosis is an important clinical goal; however, the
pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques …

Here, we sought to explore the underlying role of interleukin (IL)-8 in neutrophil extracellular
traps (NETs) formation during atherosclerosis (AS). The concentration of pro-inflammatory …

Background GBR 830 is a humanized mAb against OX40, a costimulatory receptor on
activated T cells. OX40 inhibition might have a therapeutic role in T cell–mediated diseases …

Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies
showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis …

A potential therapeutic role for immune transformation in Parkinson's disease evolves from
more than a decade of animal investigations demonstrating regulatory T cell (Treg) …

Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis.
Impaired autophagy-lysosomal degradation system leads to lipid accumulation, facilitating …