The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …
SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responses
R Tomecki, K Drazkowska… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
RNA stability and quality control are integral parts of gene expression regulation. A key
factor shaping eukaryotic transcriptomes, mainly via 3′–5′ exoribonucleolytic trimming or …
factor shaping eukaryotic transcriptomes, mainly via 3′–5′ exoribonucleolytic trimming or …
ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts
JO Rouvière, A Salerno-Kochan, S Lykke-Andersen… - Molecular Cell, 2023 - cell.com
The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II
(RNAPII) transcription termination and transcript decay. Despite its essential nature, the …
(RNAPII) transcription termination and transcript decay. Despite its essential nature, the …
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism
A Kögel, A Keidel, F Bonneau, IB Schäfer, E Conti - Molecular Cell, 2022 - cell.com
The superkiller (SKI) complex is the cytoplasmic co-factor and regulator of the RNA-
degrading exosome. In human cells, the SKI complex functions mainly in co-translational …
degrading exosome. In human cells, the SKI complex functions mainly in co-translational …
Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex
E Dubiez, E Pellegrini, MF Brask, W Garland… - Cell Reports, 2024 - cell.com
The nuclear cap-binding complex (CBC) coordinates co-transcriptional maturation,
transport, or degradation of nascent RNA polymerase II (Pol II) transcripts. CBC with its …
transport, or degradation of nascent RNA polymerase II (Pol II) transcripts. CBC with its …
Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex
AE Foucher, L Touat-Todeschini… - Nature …, 2022 - nature.com
To eliminate specific or aberrant transcripts, eukaryotes use nuclear RNA-targeting
complexes that deliver them to the exosome for degradation. S. pombe MTREC, and its …
complexes that deliver them to the exosome for degradation. S. pombe MTREC, and its …
Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is
assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly (A) …
assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly (A) …
RNA binding proteins in osteoarthritis
Q Yi, Z Deng, J Yue, J He, J Xiong, W Sun… - Frontiers in Cell and …, 2022 - frontiersin.org
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The
pathological features of OA are the erosion of articular cartilage, subchondral bone …
pathological features of OA are the erosion of articular cartilage, subchondral bone …
DEAD-box ATPase Dbp2 is the key enzyme in an mRNP assembly checkpoint at the 3'-end of genes and involved in the recycling of cleavage factors
E Aydin, S Schreiner, J Böhme, B Keil, J Weber… - Nature …, 2024 - nature.com
Abstract mRNA biogenesis in the eukaryotic nucleus is a highly complex process. The
numerous RNA processing steps are tightly coordinated to ensure that only fully processed …
numerous RNA processing steps are tightly coordinated to ensure that only fully processed …
Mechanistic insights into RNA surveillance by the canonical poly (A) polymerase Pla1 of the MTREC complex
The S. pombe orthologue of the human PAXT connection, Mtl1-Red1 Core (MTREC), is an
eleven-subunit complex that targets cryptic unstable transcripts (CUTs) to the nuclear RNA …
eleven-subunit complex that targets cryptic unstable transcripts (CUTs) to the nuclear RNA …