There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

Drug resistance is well-defined as a serious problem in our living world. To survive,
microbes develop defense strategies against antimicrobial drugs. Drugs exhibit less or no …

Abundisporin A (1), together with seven previously undescribed drimane sesquiterpenes
named abundisporins B–H (2–8), were isolated from a polypore, Abundisporus violaceus …

Due to the overuse of antibiotics, bacterial resistance has markedly increased to become a
global problem and a major threat to human health. Fortunately, in recent years, various new …

Bacterial resistance has become increasingly serious because of the widespread use and
abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a …

Emerging resistance to all available antibiotics highlights the need to develop new
antibiotics with novel mechanisms of action. Most of the currently used antibiotics target …

Pleuromutilin is an antibiotic diterpenoid made by Clitopilus passeckerianus and related
fungi, and it is the progenitor of a growing class of semi-synthetic antibiotics used in …

Abstract Purpose of Review Community-acquired bacterial pneumonia (CABP) continues to
be a worldwide health concern since it is the major cause of mortality and hospitalisation …

Identification of adverse drug events (ADEs) is crucial to reduce human health risks and
improve drug safety assessment. With an increasing number of biological and medical data …

Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant
challenge to current antibiotic treatments due to its ability to develop resistance mechanisms …