Receptor sensitivity and the mechanism of action of antidepressant treatment: Implications for the etiology and therapy of depression
DS Charney, DB Menkes… - Archives of General …, 1981 - jamanetwork.com
• Considerable evidence suggests that the acute effects of antidepressant treatments on
brain norepinephrine (NE) and serotonin (5-HT) systems cannot account fully for their …
brain norepinephrine (NE) and serotonin (5-HT) systems cannot account fully for their …
Serotonin and anxiety revisited
RS Kahn, HM Van Praag, S Wetzler, GM Asnis… - Biological Psychiatry, 1988 - Elsevier
Serotonin (5hydroxytryptamine; 5-HT) was first discovered in 1948 in blood platelets and a
few years later in the brain. Since then, investigations of 5-HT involvement in mental …
few years later in the brain. Since then, investigations of 5-HT involvement in mental …
Projections of the dorsal raphe nucleus to the brainstem: PHA‐L analysis in the rat
Early studies that used older tracing techniques reported exceedingly few projections from
the dorsal raphe nucleus (DR) to the brainstem. The present report examined DR …
the dorsal raphe nucleus (DR) to the brainstem. The present report examined DR …
The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders
G MacQueen, L Born, M Steiner - CNS Drug Reviews, 2001 - Wiley Online Library
The naphthylamine derivative sertraline is a potent and selective inhibitor of serotonin
reuptake into presynaptic terminals. Sertraline has a linear pharmacokinetic profile and a …
reuptake into presynaptic terminals. Sertraline has a linear pharmacokinetic profile and a …
Serotonin function and mechanism of action of antidepressant treatment: effects of amitriptyline and desipramine
DS Charney, GR Heninger… - Archives of General …, 1984 - jamanetwork.com
• The effects of amitriptyline hydrochloride and desipramine hydrochloride treatment on
brain serotonin (5-HT) function were investigated in 21 patients. The ability of an intravenous …
brain serotonin (5-HT) function were investigated in 21 patients. The ability of an intravenous …
Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors
P Blier, C De Montigny - Neuroscience, 1985 - Elsevier
Repeated administration of monoamine oxidase inhibitors induces a transient decrease in
the firing rate of serotoninergic neurons followed by complete recovery, whereas it results in …
the firing rate of serotoninergic neurons followed by complete recovery, whereas it results in …
Anatomical relationships between the ventral mesencephalic tegmentum—a 10 region and the locus coeruleus as demonstrated by anterograde and retrograde …
H Simon, M Le Moal, L Stinus, A Calas - Journal of neural transmission, 1979 - Springer
We have searched for anatomical connections between the ventral mesencephalic
tegmentum (VMT), including the dopaminergic cell group A10 and the locus coeruleus (LC) …
tegmentum (VMT), including the dopaminergic cell group A10 and the locus coeruleus (LC) …
Raphe projections to the locus coeruleus in the rat
PJ Morgane, MS Jacobs - Brain research bulletin, 1979 - Elsevier
Afferent projections to the locus coeruleus from the various raphe nuclei, particularly of the
midbrain (nuclei raphe dorsalis and medianus) and pons (nuclei raphe pontis and magnus) …
midbrain (nuclei raphe dorsalis and medianus) and pons (nuclei raphe pontis and magnus) …
Serotonin: a common neurobiologic substrate in anxiety and depression
MS EISON - Journal of Clinical Psychopharmacology, 1990 - journals.lww.com
Anxiety and depression have traditionally been considered independent pathologies.
Recent evidence suggests that these disorders may be related. Some tricyclic …
Recent evidence suggests that these disorders may be related. Some tricyclic …
Serotonin nerve terminals in the locus coeruleus of adult rat: a radioautographic study
L Leger, L Descarries - Brain research, 1978 - Elsevier
Abstract Serotonin (5-HT) nerve terminals in the locus coeruleus (LC) of adult rat were
visualized by high-resolution radioautography, in order to examine their distribution, fine …
visualized by high-resolution radioautography, in order to examine their distribution, fine …