• Considerable evidence suggests that the acute effects of antidepressant treatments on
brain norepinephrine (NE) and serotonin (5-HT) systems cannot account fully for their …

Serotonin (5hydroxytryptamine; 5-HT) was first discovered in 1948 in blood platelets and a
few years later in the brain. Since then, investigations of 5-HT involvement in mental …

Early studies that used older tracing techniques reported exceedingly few projections from
the dorsal raphe nucleus (DR) to the brainstem. The present report examined DR …

The naphthylamine derivative sertraline is a potent and selective inhibitor of serotonin
reuptake into presynaptic terminals. Sertraline has a linear pharmacokinetic profile and a …

• The effects of amitriptyline hydrochloride and desipramine hydrochloride treatment on
brain serotonin (5-HT) function were investigated in 21 patients. The ability of an intravenous …

Repeated administration of monoamine oxidase inhibitors induces a transient decrease in
the firing rate of serotoninergic neurons followed by complete recovery, whereas it results in …

We have searched for anatomical connections between the ventral mesencephalic
tegmentum (VMT), including the dopaminergic cell group A10 and the locus coeruleus (LC) …

Afferent projections to the locus coeruleus from the various raphe nuclei, particularly of the
midbrain (nuclei raphe dorsalis and medianus) and pons (nuclei raphe pontis and magnus) …

Anxiety and depression have traditionally been considered independent pathologies.
Recent evidence suggests that these disorders may be related. Some tricyclic …

Abstract Serotonin (5-HT) nerve terminals in the locus coeruleus (LC) of adult rat were
visualized by high-resolution radioautography, in order to examine their distribution, fine …