Background Metformin is the most widely prescribed drug to lower glucose and has a
definitive effect on the cardiovascular system. The goal of this systematic review and meta …

Background: Clinicians and patients need updated evidence on the comparative
effectiveness and safety of diabetes medications to make informed treatment choices …

The purpose of this review article is to understand the current literature on obesity, diabetes
and therapeutic avenues across the world. Diabetes is a chronic lifestyle condition that …

Aims Clinical and observational studies have shown an increased risk of cardiovascular
events and death associated with sulphonylureas versus metformin. However, it has never …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on oral pharmacologic treatment of type …

Electronic health records (EHRs) present a wealth of data that are vital for improving patient-
centered outcomes, although the data can present significant statistical challenges. In …

Background Sulfonylureas are common second-line options for management of type 2
diabetes; however, they are associated with a higher risk of cardiovascular events compared …

Recent randomized trials have compared the newer antidiabetic agents to treatments
involving sulfonylureas, drugs associated with increased cardiovascular risks and mortality …

The selection of a glycemic goal in a person with diabetes is a compromise between the
documented upside of glycemic control—the partial prevention or delay of microvascular …

Objective To evaluate the effectiveness and safety of metformin use in clinical practice in a
large sample of pharmacologically treated patients with type 2 diabetes and different levels …